Dr. Notario's research focuses on the study of molecular mechanisms of oncogenesis and involves the investigation of the effects of environmental carcinogens, such as chemical pollutants and radiation, on mammalian cells with regard to the expression and activity of cancer genes and their protein products. Recently, Dr. Notario's research group isolated a novel oncogene, termed cph, which is conserved in eukaryotic cells from yeast to humans, and cooperates with other oncogenes such as ras in the neoplastic transformation of mammalian cells. Ongoing studies are centered on characterizing the structure and regulation of the cph gene and its product. Transgenic and knock-out mouse strains are being generated to study cph function. Related areas of research investigate the action of carcinogens on the structure and expresion of the p53 tumor suppressor gene, the effect of alterations of oncogenes on the cellular response to radiation, as well as the anti-cancer actions of human dietary components. Dr. Notario's research has been continuously funded by the National Institutes of Health from 1989 through 2007.