Contribution of hTERT in prostate cancer metastasis
Telomerase is a complex ribonucleoprotein enzyme with reverse transcriptase activity that is responsible for the extension of telomeric DNA. Recent literature indicates that telomerase has additional functions than to stabilizing chromosome ends. Telomerase can enhance cancer cell proliferation by increasing the transcription of growth controlling genes and promote survival by abating apoptosis and regulating cell cycle genes. In this project, we are investigating the extra-telomeric role of hTERT in prostate cancer progression.