The Fornace laboratory focuses on signal transduction and abnormalities in cancer. The laboratory has made important contributions in defining the roles for key tumor suppressor pathways in cancer prevention, and their perturbations that contribute to tumor development and resistance to cancer therapy. Many of these important pathways impact on signaling mechanisms controlling cell death, apoptosis, which have potential in prostate cancer therapy. The laboratory previously received a Department of Defense Award to study death receptors, such as TRAIL, and their roles in mediating apoptotic signaling in prostate cancer. A new line of research focuses on targeting a oncogenic phosphatase that blocks apoptosis and related protective responses; for more details see: "Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis". Cancer Biol Ther 4: 1154-1158, 2005.