Scatter factor protects prostate cancer cells against apoptosis

Eliot Rosen

Scatter factor (SF) [also known as hepatocyte growth factor (HGF)] and its receptor c-Met (a proto-oncogene product) are frequently over-expressed in human prostate cancer; and their over-expression correlates with a poor prognosis. Our studies indicate that SF renders human prostate carcinoma cells resistant to cancer chemotherapy drugs (eg., adriamycin), TRAIL (TNF-related apoptosis-inducing ligand), and oxidative stress. Our research is focused on determining the molecular mechanisms through which SF protects prostate cancer against cell killing. The elucidation of potential SF-mediated protective pathways may allow us to develop novel methods for chemosensitization and radiosensitization of prostate cancers in the clinic.