AIB1 Integration of Hormonal and Growth Factor Signals
Dr Riegel's lab works on the coactivator AIB1 that integrates hormonal and growth factor signals towards cell survival and growth. AIB1 is strongly upregulated in invasive prostate cancer relative to normal prostate tissues. AIB1 is further upregulated in metastatic prostate cancer tissues. Understanding and blocking the function of AIB1 by preventing its interaction with signal transduction proteins as well as its posttranslational modifications is the focus of ongoing work.